Prdm16 Supports Arterial Flow Recovery by Maintaining Endothelial Function

Circ Res. 2021 Jun 25;129(1):63-77. doi: 10.1161/CIRCRESAHA.120.318501. Epub 2021 Apr 27.

Sander Craps¹, Jore Van Wauwe¹, Sofie De Moudt², Dorien De Munck², Arthur J A Leloup², Bram Boeckx^{3

4}, Tim Vervliet⁵, Wouter Dheedene¹, Nathan Criem¹, Carla Geeroms^{6

7}, Elizabeth A V Jones¹, An Zwijsen¹, Diether Lambrechts^{3

4}, Paul Fransen², Manu Beerens^#^{1

8}, Aernout Luttun^#¹

¹ Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology (S.C., J.V.W., W.D., N.C., E.A.V.J., A.Z., M.B., A.L.), KU Leuven, Leuven, Belgium.
² Pharmaceutical Sciences, Physiopharmacology, University of Antwerp, Antwerp, Belgium (S.D.M., D.D.M., A.J.A.L., P.F.).
³ Laboratory for Translational Genetics, Department of Human Genetics (B.B., D.L.), KU Leuven, Leuven, Belgium.
⁴ VIB Center for Cancer Biology, Leuven, Belgium (B.B., D.L.).
⁵ Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine (T.V.), KU Leuven, Leuven, Belgium.
⁶ Prometheus, Division of Skeletal Tissue Engineering (C.G.), KU Leuven, Leuven, Belgium.
⁷ Skeletal Biology and Engineering Research Center, Department of Development and Regeneration (C.G.), KU Leuven, Leuven, Belgium.
⁸ Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA (M.B.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: arteries; endothelium; homeostasis; ischemia; transcription factor; vasodilation.