Dosimetric impact from cardiac motion to heart substructures in thoracic cancer patients treated with a magnetic resonance guided radiotherapy system

Ran Yan; Fang-I Chu; Yu Gao; Victoria Yu; Stephanie Yoon; David Elashoff; Percy Lee; Peng Hu; Yingli Yang

doi:10.1016/j.phro.2020.11.005

Dosimetric impact from cardiac motion to heart substructures in thoracic cancer patients treated with a magnetic resonance guided radiotherapy system

Phys Imaging Radiat Oncol. 2020 Dec 18:17:8-12. doi: 10.1016/j.phro.2020.11.005. eCollection 2021 Jan.

Authors

Ran Yan^{1

2}, Fang-I Chu³, Yu Gao¹, Victoria Yu¹, Stephanie Yoon³, David Elashoff⁴, Percy Lee⁵, Peng Hu¹, Yingli Yang³

Affiliations

¹ Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
² Department of Bioengineering, University of California, Los Angeles, CA, USA.
³ Department of Radiation Oncology, University of California, Los Angeles, CA, USA.
⁴ Department of Biostatistics, University of California, Los Angeles, CA, USA.
⁵ Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.

Abstract

Few studies have examined the cardiac volume and radiation dose differences among cardiac phases during radiation therapy (RT). Such information is crucial to dose reconstruction and understanding of RT related cardiac toxicity. In a cohort of nine patients, we studied the changes in the volume and doses of several cardiac substructures between the end-diastolic and end-systolic phases based on the clinical magnetic resonance-guided RT (MRgRT) treatment plans. Significant differences in the volume and dose between the two phases were observed. Onboard cardiac cine MRI holds promise for patient-specific cardiac sparing treatment designs.

Keywords: CINE MRI; Cardiac substructures; Dosimetry analysis; MRgRT.