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Biochim Biophys Acta. 1988 Jul 1;961(1):30-7.

Formation and excretion of branched-chain acylcarnitines and branched-chain hydroxy acids in the perfused rat kidney.

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Institute of Medical Biochemistry, University of Oslo, Norway.


alpha-Keto[U-14C]isovalerate, alpha-keto[U-14C]isocaproate and alpha-keto[U-14C]beta-methylvalerate are metabolized in the perfused kidney. Labelled 3-hydroxyisobutyrate, 3-hydroxyisovalerate, 2-methyl-3-hydroxybutyrate, branched-chain amino acids, branched-chain acylcarnitines and lactate are formed. Hydroxy acids and acylcarnitines are excreted preferentially in the urine, whereas the branched-chain amino acids are preferentially excreted in the perfusate. There is no accumulation of (U-14C)-labelled alpha-keto acids or labelled metabolites in the kidney during perfusion. (-)-Carnitine accumulates rapidly in the kidney when it is added to the perfusate. A high kidney carnitine level enhances the excretion of carnitine esters in the urine.

[Indexed for MEDLINE]

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