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Ann Neurol. 1988 Apr;23(4):416-8.

Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: human cerebral infarction studied by serial 31P NMR spectroscopy.

Author information

1
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.

Abstract

We report on a patient with a large ischemic hemispherical stroke studied serially by 31P nuclear magnetic resonance spectroscopy. Persistent hyperglycemia was associated with prolonged acidosis in ischemic brain and failure of high-energy phosphate metabolism to recover. These in vivo human data support the concept that hyperglycemia adversely affects ischemic brain metabolism, pH, and clinical outcome.

PMID:
3382181
DOI:
10.1002/ana.410230423
[Indexed for MEDLINE]

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