Send to

Choose Destination
See comment in PubMed Commons below
Mol Biochem Parasitol. 1988 Feb;28(1):55-62.

Role of mannose/N-acetylglucosamine receptors in blood clearance and cellular attachment of Leishmania donovani.

Author information

Indian Institute of Chemical Biology, Calcutta.


The effects of glycoproteins and neoglycoproteins specific for liver and macrophage membrane lectins on both the cellular attachment and the clearance of Leishmania donovani from hamster blood were investigated. Although the inhibition pattern of in vitro cellular attachment studies indicates the involvement of both galactose and mannose/N-acetylglucosamine receptors, the in vivo blood clearance of the parasites was inhibited only by glycoproteins and neoglycoproteins specific for mannose/N-acetylglucosamine receptors. The inhibitory effects on blood clearance were abolished by pretreating the parasites with tunicamycin, an inhibitor of protein glycosylation. These results indicate that the mannose/N-acetylglucosamine hepatic lectin recognizes specific sugars on the parasite surface and is important to the promastigote during the early stages of infection.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center