Send to

Choose Destination
Can J Vet Res. 1988 Apr;52(2):236-8.

Detection of antibodies to mouse thymic virus by enzyme-linked immunosorbent assay.

Author information

Centre de Recherche en Virologie, Institut Armand-Frappier, Laval-des-Rapides, Laval, Québec.


Enzyme-linked immunosorbent assay was used to detect serum antibodies to mouse thymic virus, a herpesvirus that causes thymic lesions and immunosuppression. Antibodies were detected in mice that had received single or multiple injections of the virus and were also found in mice housed in contact with the experimentally infected animals. By contrast, mice not exposed to mouse thymic virus or those inoculated with an uninfected thymus preparation remained seronegative. A serological survey of eight mouse colonies revealed one positive colony, confirmed by virus isolation. These results show that the test is sufficiently sensitive and specific to be used for routine screening of mice.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center