Stabilizing Formative Pluripotent States with Germ Cell Competency

Ng Shyh-Chang; Lei Li

doi:10.1016/j.stem.2021.02.021

Stabilizing Formative Pluripotent States with Germ Cell Competency

Cell Stem Cell. 2021 Mar 4;28(3):361-363. doi: 10.1016/j.stem.2021.02.021.

Authors

Ng Shyh-Chang¹, Lei Li²

Affiliations

¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Beijing Institute of Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: huangsq@ioz.ac.cn.
² State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Beijing Institute of Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China. Electronic address: lil@ioz.ac.cn.

PMID: 33667353
DOI: 10.1016/j.stem.2021.02.021

Abstract

Previous work demonstrating the existence of intermediate pluripotency states in post-implantation embryos had ignited a debate on whether "formative" pluripotency can be stabilized in pluripotent stem cell (PSC) lines. In this issue of Cell Stem Cell, two papers show that polarized epithelial and germ cell-competent formative PSCs can be maintained in modified activin-dependent conditions.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Activins
Animals
Embryonic Development
Germ Cells
Humans
Mice
Pluripotent Stem Cells*

Substances

Activins

Grants and funding

HHMI/Howard Hughes Medical Institute/United States