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Eur J Pediatr. 1988 Feb;147(2):197-8.

Low serum C4 concentrations in type-1 diabetes mellitus.

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Clinica Pediatrica, Ospedale Pediatrico, Chieti, Italy.


Serum levels of complement factors C3 and C4 were investigated in 64 insulin-dependent diabetic children and 52 healthy controls. The mean value of C4 was significantly lower in diabetic than in control subjects (27.99 +/- 8.01 vs 32.03 +/- 8.91 mg/dl; P less than 0.01). Sixteen out of 64 children had serum C4 levels below the normal range; 6 out of these 11 patients had microalbuminuria. This study demonstrates low serum levels of C4 in insulin-dependent diabetes; this reduction is not related to the duration nor to the degree of metabolic control. There is a high prevalence of microalbuminuria in patients with a low C4 concentration.

[Indexed for MEDLINE]

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