Send to

Choose Destination
Clin Nephrol. 1988 Apr;29(4):193-8.

Pregnancy in women with diffuse mesangial proliferative glomerulonephritis.

Author information

Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.


The clinical course of 168 pregnancies in 91 women with non-IgA diffuse mesangial proliferative glomerulonephritis has been analyzed. Twenty percent (33) of pregnancies resulted in fetal loss, 18% (31) in premature delivery and 62% (105) in a term infant. Maternal renal function declined, reversibly, in 3% (5) of pregnancies and in 48% (80) hypertension developed. In 53% (89) a significant increase in proteinuria occurred in pregnancy. Fetal and maternal complications of pregnancy occurred more frequently in patients with pre-existing hypertension although differences failed to reach statistical significance (p greater than 0.01). The presence of severe vessel lesions on the diagnostic renal biopsy was associated with a significantly higher fetal loss and prematurity rate (p less than 0.0005 and p less than 0.005, respectively).

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center