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Clin Nephrol. 1988 Apr;29(4):176-8.

Acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine.

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1
Nephrology Service, Hospital Clínic i Provincial, Barcelona, Spain.

Abstract

We report 5 cases of acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine. Four patients complained of visual toxicity characterized by a decrease in visual acuity, loss of color vision and night blindness. In these patients there was a decrease in visual acuity, and the Farnsworth's test revealed a tritanopy (yellow-blue axis impairment); 1 patient also showed retinal pigmentary changes. A fifth patient complained of bilateral and severe neurosensorial deafness. Patients improved clinically upon drug-withdrawal. We recommend careful monitoring of audiovisual toxicity in patients with end-stage renal disease receiving this drug.

PMID:
3365862
[Indexed for MEDLINE]

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