Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1988 Apr 29;152(2):534-9.

Presence of benzodiazepine-like molecules in mammalian brain and milk.

Author information

1
Instituto de Biología Celular, Facultad de Medicina, Buenos Aires, Argentina.

Abstract

From bovine cerebral cortex extracts, used to isolate n-butyl beta carboline-3-carboxylate (8), fractions active in displacing [3H] flunitrazepam binding were purified and shown to contain benzodiazepine-like molecules. These were recognized by UV spectra, retention time in HPLC, and interaction with a specific monoclonal antibody. Such molecules were localized in synaptic vesicles and cytosol of synaptosomes. Similar molecules were also found in cow milk. The possible dietary origin of these benzodiazepine-like molecules is discussed.

PMID:
3365238
DOI:
10.1016/s0006-291x(88)80070-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center