Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

Yongcun Qu; Qi Chen; Shanshan Guo; Chiyuan Ma; Yonggang Lu; Junchao Shi; Shichao Liu; Tong Zhou; Taichi Noda; Jingjing Qian; Liwen Zhang; Xili Zhu; Xiaohua Lei; Yujing Cao; Wei Li; Wei Li; Nicolas Plachta; Martin M Matzuk; Masahito Ikawa; Enkui Duan; Ying Zhang; Hongmei Wang

doi:10.1007/s13238-021-00825-y

Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization

Protein Cell. 2021 Oct;12(10):810-817. doi: 10.1007/s13238-021-00825-y. Epub 2021 Mar 1.

Authors

Yongcun Qu^#^{1

2}, Qi Chen^#³, Shanshan Guo^#^{1

2}, Chiyuan Ma¹, Yonggang Lu⁴, Junchao Shi³, Shichao Liu³, Tong Zhou⁵, Taichi Noda⁴, Jingjing Qian^{1

2}, Liwen Zhang^{1

2}, Xili Zhu¹, Xiaohua Lei¹, Yujing Cao¹, Wei Li^{1

6}, Wei Li^{1

6}, Nicolas Plachta⁷, Martin M Matzuk⁸, Masahito Ikawa⁴, Enkui Duan^{9

10}, Ying Zhang^{11

12

13

14}, Hongmei Wang^{15

16

17}

Affiliations

¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, 92521, USA.
⁴ Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.
⁵ Department of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.
⁶ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁷ Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore.
⁸ Center for Drug Discovery, Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
⁹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. duane@ioz.ac.cn.
¹⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. duane@ioz.ac.cn.
¹¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. yingzhanglab@gmail.com.
¹² Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. yingzhanglab@gmail.com.
¹³ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. yingzhanglab@gmail.com.
¹⁴ The Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, Beijing Normal University, Beijing, 100875, China. yingzhanglab@gmail.com.
¹⁵ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. wanghm@ioz.ac.cn.
¹⁶ University of Chinese Academy of Sciences, Beijing, 100049, China. wanghm@ioz.ac.cn.
¹⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. wanghm@ioz.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigens, Surface / genetics*
Cell Communication / genetics*
Copulation / physiology
Fallopian Tubes / anatomy & histology
Fallopian Tubes / metabolism*
Female
Fertilization / genetics*
GPI-Linked Proteins / deficiency
GPI-Linked Proteins / genetics
Gene Expression Regulation
Genes, Reporter
Green Fluorescent Proteins / genetics
Green Fluorescent Proteins / metabolism
Litter Size
Luminescent Proteins / genetics
Luminescent Proteins / metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria / metabolism
Reproduction / genetics*
Signal Transduction
Sperm Count
Sperm Motility / genetics
Spermatozoa / metabolism*
Uterus / anatomy & histology
Uterus / metabolism

Substances

Antigens, Surface
GPI-Linked Proteins
Luminescent Proteins
TEX101 protein, mouse
enhanced green fluorescent protein
fluorescent protein 583
Green Fluorescent Proteins

Publication types

MeSH terms

Substances

Grants and funding