Calcitonin Gene-Related Peptide Protects Against Cardiovascular Dysfunction Independently of Nitric Oxide In Vivo

Hypertension. 2021 Apr;77(4):1178-1190. doi: 10.1161/HYPERTENSIONAHA.120.14851. Epub 2021 Mar 1.

Abstract

[Figure: see text].

Keywords: atherosclerosis; blood pressure; fibrosis; nitric oxide; vasodilation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcitonin Gene-Related Peptide* / metabolism
  • Calcitonin Gene-Related Peptide* / pharmacology
  • Cardiotonic Agents / metabolism
  • Cardiotonic Agents / pharmacology
  • Cardiovascular Diseases* / metabolism
  • Cardiovascular Diseases* / prevention & control
  • Cardiovascular System / drug effects
  • Cardiovascular System / metabolism
  • Cardiovascular System / physiopathology
  • Drug Discovery
  • Endothelium, Vascular / metabolism*
  • Hypertension / metabolism*
  • Hypertension / physiopathology
  • Mice
  • Mice, Knockout
  • Microvessels / metabolism
  • Microvessels / physiopathology
  • Nitric Oxide Synthase Type III / metabolism*
  • Receptors, Calcitonin Gene-Related Peptide / metabolism
  • Vascular Remodeling / drug effects
  • Vasodilation / physiology

Substances

  • Cardiotonic Agents
  • Receptors, Calcitonin Gene-Related Peptide
  • Nitric Oxide Synthase Type III
  • Nos3 protein, mouse
  • Calcitonin Gene-Related Peptide