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Brain Res. 1988 Feb 16;441(1-2):403-7.

Blockade of the histamine H1-receptor in the rat ventromedial hypothalamus and feeding elicitation.

Author information

1
Department of Internal Medicine I, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Abstract

All H1-, but no H2-antagonists infused into the rat third cerebroventricle, induced feeding during the early light, but not during the early dark, reflecting a concentration of hypothalamic histamine. Bilateral microinfusion identified the ventromedial hypothalamus (VMH), but not the lateral hypothalamus or the paraventricular nucleus, as a main locus for the induction of feeding by an H1-antagonist. The effect was completely abolished when brain histamine was decreased by pretreatment with alpha-fluoromethylhistidine. Hypothalamic neuronal histamine suppresses food intake, at least in part, through H1-receptors in the VMH.

PMID:
3359243
DOI:
10.1016/0006-8993(88)91423-0
[Indexed for MEDLINE]

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