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Br J Pharmacol. 1988 Feb;93(2):243-5.

Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens.

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Department of Physiology, University of Leicester.


The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 microM, Suramin antagonized the response to alpha,beta-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2-purinoceptors.

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