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Proc Natl Acad Sci U S A. 1988 Apr;85(8):2815-9.

Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization.

Author information

1
Department of Medicine, University of California, San Francisco 94143.

Abstract

The human immunodeficiency virus (HIV) type 1 displays a high degree of genetic variation, especially in the glycoprotein (gp120) domain of the envelope gene. To determine whether this genomic heterogeneity leads to the expression of independent HIV subtypes, 12 sera from HIV type 1 antibody-positive individuals were tested for their ability to neutralize 20 HIV isolates of various origins. Four distinct HIV subtypes with different sensitivity to serum neutralization were identified. These results suggest that a finite number of HIV subtypes exist and that the combined use of selected HIV isolates representing several subtypes may be necessary for the development of an effective vaccine.

PMID:
3357892
PMCID:
PMC280090
DOI:
10.1073/pnas.85.8.2815
[Indexed for MEDLINE]
Free PMC Article

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