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Nature. 1988 Apr 7;332(6164):509-14.

A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe.

Author information

1
Cold Spring Harbor Laboratory, New York 11724.

Abstract

In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting its enzymatic activity. Inactivation of the ran1+ protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation.

PMID:
3357510
DOI:
10.1038/332509a0
[Indexed for MEDLINE]

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