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Biochem Med Metab Biol. 1988 Feb;39(1):121-5.

Liver aspartate aminotransferase activity as a power function of body weight.

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Department of Research, Wm. Jennings Bryan Dorn Veterans Hospital Medical Center, Columbia, South Carolina.


Total liver enzyme activity (E) for aspartate aminotransferase (ASAT; EC per gram body weight (W) decreases in six species as body weight increases from mice to cattle according to the equation E/W 0.85 = c, where c is a constant. The 0.85 power of body weight thereby provides a reference standard for the direct arithmetic comparison of liver ASAT activities in six species with different body weights. The use of W 0.85 should provide a tool in clinical studies in which data from experimental animals must be related to humans, e.g., in establishing the relationship between drug dosage (or toxicity) and body weight.

[Indexed for MEDLINE]

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