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Biochem Biophys Res Commun. 1988 Mar 30;151(3):1173-9.

5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue.

Author information

1
Department of Pathology, New York University School of Medicine, New York, NY 10016.

Abstract

The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.

PMID:
3355548
DOI:
10.1016/s0006-291x(88)80489-3
[Indexed for MEDLINE]

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