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Clin Neuropharmacol. 1988 Feb;11(1):36-44.

Continuous duodenal infusions of levodopa: plasma concentrations and motor fluctuations in Parkinson's disease.

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1
Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick 08903.

Abstract

Four parkinsonian patients received continuous duodenal infusions of levodopa (LD) for severe "on-off" phenomena associated with Sinemet (carbidopa/levodopa) therapy. All patients had marked decreases in motor fluctuations on the infusions compared with tablets. Two factors that appear related to this improvement are the ability of duodenal infusions to produce steadier plasma LD concentrations and/or to maintain LD concentrations above a minimum threshold needed to achieve the "on" state.

PMID:
3349496
[Indexed for MEDLINE]
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