Send to

Choose Destination
See comment in PubMed Commons below
Am J Vet Res. 1988 Feb;49(2):245-9.

Effects of phenobarbital on thiopental pharmacokinetics in greyhounds.

Author information

  • 1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.


The effects of phenobarbital on the pharmacokinetics of thiopental (15 mg/kg IV) were investigated in 12 trained racing Greyhounds. Phenobarbital (16 mg/kg of body weight, PO, q 24 h), administered for 14 days, reduced the area under the curve of plasma concentration of thiopental vs time from 10,688 micrograms.min/ml to 3,224 micrograms.min/ml. Furthermore, the time to recovery from anesthesia (ie, return to standing position) decreased from 103 minutes to 35.7 minutes after phenobarbital. These effects were attributed to an increase in the metabolic clearance of thiopental, as a result of induction of liver enzyme activity by phenobarbital. These results suggested that hepatic metabolism, in addition to distribution, is a factor that must be considered when assessing the difference in drug disappearance rates between Greyhounds and other breeds of dogs.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center