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FEBS Lett. 1988 Mar 14;229(2):377-82.

Iron- and manganese-containing superoxide dismutases can be distinguished by analysis of their primary structures.

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1
European Molecular Biology Laboratory (EMBL), Heidelberg, FRG.

Abstract

The iron- and manganese-containing superoxide dismutases have very similar three-dimensional structures but can be distinguished by various biochemical means. The primary structures of six manganese-containing and three iron-containing superoxide dismutases are known. Analysis of the aligned amino acid sequences of these enzymes taken together with structural data from X-ray diffraction studies demonstrates that the two classes of enzyme can be distinguished on the basis of a small number of single-site substitutions that are positioned in and close to the active site of the enzyme.

PMID:
3345848
DOI:
10.1016/0014-5793(88)81160-8
[Indexed for MEDLINE]
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