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Ophthalmology. 1988 Jan;95(1):56-60.

Nanophthalmic sclera. Fibronectin studies.

Author information

1
Department of Ophthalmology, University of Illinois at Chicago, Lions of Illinois Eye Research Institute 60612.

Abstract

The authors performed fibronectin studies on scleral specimens derived from a patient with nanophthalmos. Immunohistochemical staining with antifibronectin was conducted using both formaldehyde-fixed, paraffin-embedded tissue sections and unfixed tissue-cultured scleral cells. In each case, the nanophthalmic samples exhibited fibronectin staining stronger than that obtained from normal human subjects. Results from an enzyme-linked immunosorbent assay (ELISA) confirmed the histologic findings that, in tissue culture, the patient's scleral cells contained and secreted a higher amount of fibronectin than did the normal control cells. The elevated fibronectin level may be related to the development of nanophthalmos.

PMID:
3344125
DOI:
10.1016/s0161-6420(88)33215-x
[Indexed for MEDLINE]

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