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Exp Parasitol. 1988 Feb;65(1):1-9.

Leishmania braziliensis panamensis: increased infectivity resulting from heat shock.

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Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20307-5100.


Promastigotes of Leishmania braziliensis panamensis were subjected to a heat shock transformation yielding an amastigote-like stage. During the process of conversion, the heat-induced differentiating form displayed an increase in infectivity (as determined by lesion size) accompanied by a total protein composition unlike that of the promastigote and a morphology resembling that of the amastigote. These biological/functional changes may be related to an involvement of a heat shock response in the differentiation of leishmania, thus having important implications in the development of prevention and treatment stratagems.

[Indexed for MEDLINE]

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