Emerging roles of SIRT6 in human diseases and its modulators

Med Res Rev. 2021 Mar;41(2):1089-1137. doi: 10.1002/med.21753. Epub 2020 Dec 16.

Abstract

The biological functions of sirtuin 6 (SIRT6; e.g., deacetylation, defatty-acylation, and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric maintenance. Over the past decades, the aberration of SIRT6 has been extensively observed in diverse life-threatening human diseases. In this comprehensive review, we summarize the critical roles of SIRT6 in the onset and progression of human diseases including cancer, inflammation, diabetes, steatohepatitis, arthritis, cardiovascular diseases, neurodegenerative diseases, viral infections, renal and corneal injuries, as well as the elucidation of the related signaling pathways. Moreover, we discuss the advances in the development of small molecule SIRT6 modulators including activators and inhibitors as well as their pharmacological profiles toward potential therapeutics for SIRT6-mediated diseases.

Keywords: SIRT6; activators; deacetylation; defatty-acylation; human diseases; inhibitors; mono-ADP-ribosylation; small molecule modulators.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aging
  • DNA Repair
  • Humans
  • Longevity
  • Neoplasms* / drug therapy
  • Sirtuins* / genetics
  • Sirtuins* / metabolism

Substances

  • SIRT6 protein, human
  • Sirtuins