Send to

Choose Destination
Trans R Soc Trop Med Hyg. 1987;81(6):907-9.

The complete development in vitro of the vertebrate phase of the mammalian malarial parasite Plasmodium berghei.

Author information

Department of Pure and Applied Biology, Imperial College, London.


All three 'vertebrate' stages of the rodent malarial parasite Plasmodium berghei berghei were grown in vitro in the absence of the vertebrate host. The parasite was introduced into culture from infected mosquitoes and 2 in vitro culture methods were used sequentially to complete the 'vertebrate' phases of development in hepatoma and erythrocyte host cells. The resultant blood infection produced mature schizonts and male and female gametocytes. The protocol, which is now being extended to the human pathogen P. falciparum, may assist future studies on this important group of parasites.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center