Format

Send to

Choose Destination
Anticancer Res. 1987 Nov-Dec;7(6):1299-304.

Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue.

Author information

1
Beatson Institute for Cancer Research, Bearsden, Glasgow, Scotland, U.K.

Abstract

Expression of the c-myc gene in human breast lesions and in adjacent normal tissue was studied by immunohistochemical analysis. The previously described monoclonal antibody Myc1-9E10 (1) which recognizes the p62 c-myc protein was used in paraffin tissue sections. A total of 101 cases of breast disease examined included 38 simple and complex cystic disease, 18 simple and hyperplastic fibroadenomas, 36 ductal and lobular carcinomas and 9 in situ carcinomas. Whereas the adjacent normal tissue was slightly positive, 25 out of 38 cystic disease, 7 out of 18 fibroadenoma, 36 out of 36 carcinoma and 9 out of 9 in situ carcinoma specimens showed moderate to high levels of p62 c-myc expression as indicated by staining intensity. These results suggest that the c-myc protein may play a role in breast neoplasia.

PMID:
3327455
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center