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Eur J Pharmacol. 1987 Dec 15;144(3):389-92.

Stereoselective inhibition of chloride transport by loop diuretics in pancreatic beta-cells.

Author information

1
Department of Histology and Cell Biology, University of Umeå, Sweden.

Abstract

The effects of loop diuretics on 36Cl- uptake was tested in isolated beta-cell-rich pancreatic islets. Bumetanide reduced the 36Cl- influx and the levorotatory form of ozolinone reduced both the influx and equilibrium content of 36Cl- in the islets, whereas the dextrorotatory form was largely inactive. The data suggest that the beta-cells are equipped with a loop diuretic-sensitive system for 36Cl- uptake and that this system is confined to a sterically well-defined structure.

PMID:
3326748
DOI:
10.1016/0014-2999(87)90394-3
[Indexed for MEDLINE]

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