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Maturitas. 1987 Nov;9(3):227-34.

Effect of Bellergal Retard on climacteric complaints: a double-blind, placebo-controlled study.

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Department of Obstetrics and Gynaecology, Maria Ziekenhuis, Tilburg, The Netherlands.


The effect of Bellergal Retard (BR) on climacteric complaints was evaluated versus a placebo in an 8-wk double-blind study, followed by a 4-wk open study in which only BR was used as medication. There was a marked decrease in complaints in both the BR and the placebo groups. Statistically significant differences were observed between the groups after 2 and 4 wk of treatment, indicating superior results with BR. After 8 wk of study however, these differences were no longer apparent. It was concluded that studies on medication for climacteric complaints should not only be placebo-controlled, but also be of at least 8 to 12 wk duration for proper evaluation.

[Indexed for MEDLINE]

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