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J Protozool. 1987 Nov;34(4):416-7.

Self-splicing RNA and an RNA enzyme in Tetrahymena.

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Department of Chemistry and Biochemistry, University of Colorado, Boulder, 80309-0215.


The RNA molecules transcribed from many eukaryotic genes are interrupted by intervening sequences, which are removed by a process called RNA splicing. One structurally related group of intervening sequences, the group I intervening sequences, are found in a variety of microorganisms. Some of these, including the group I intervening sequence from the ribosomal RNA precursor of Tetrahymena thermophila, have been shown to mediate their own splicing in an RNA-catalyzed reaction. Following its excision from the ribosomal RNA precursor, the Tetrahymena intervening sequence acts as an enzyme, cutting and rejoining RNA substrates.

[Indexed for MEDLINE]

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