Format

Send to

Choose Destination
J Antimicrob Chemother. 1987 Nov;20(5):631-8.

Induction of the SOS response by new 4-quinolones.

Author information

1
Department of Microbiology, Hospital Ramon y Cajal, Madrid, Spain.

Abstract

The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE- background, provided there was a functioning SOS system.

PMID:
3323160
DOI:
10.1093/jac/20.5.631
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center