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Diabetologia. 1987 Oct;30(10):769-73.

Postprandial oscillations of plasma glucose, insulin and C-peptide in man.

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1
Service de M├ędecine Interne CHU Hautepierre, Strasbourg, France.

Abstract

Postprandial plasma glucose, insulin and C-peptide profiles were studied in eight normal subjects, in the afternoon or in the evening. Two to five synchronous oscillations, with a mean period of 51 to 112 min were detected. The oscillations were highest after meals and were then damped, reverting to fasting levels after up to 340 min. Additional short-term oscillations, with periods of 20-30 min and 9-14 min, were observed. Cross-correlation studies of glucose and insulin and of insulin and C-peptide revealed a high correlation in the frequency bands considered. The synchronous oscillations of insulin and C-peptide suggest cyclic variations in pancreatic secretion rather than cyclic changes in insulin degradation.

PMID:
3322902
DOI:
10.1007/bf00275742
[Indexed for MEDLINE]

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