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Mycopathologia. 1987 Oct;100(1):27-35.

Action of chlorhexidine on budding Candida albicans: scanning and transmission electron microscopic study.

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Laboratoire de Biologie Végétale et Cryptogamie, Faculté de Pharmacie, Reims, France.


Chlorhexidine is widely used as a bacterial drug whose method of action has been well described in bacteria. Its fungicidal properties have been proved. We show here the effects of a sublethal dose of a preparation of digluconate of chlorhexidine on budding Candida albicans. A fungistatic action is revealed by a decrease in the percentage of budding cells, and two main types of alterations can be observed with transmission electron microscopy (T.E.M.): a loss of cytoplasmic components and a coagulation of nucleoproteins. With scanning electron microscopy (S.E.M.), the cell walls show morphological modifications.

[Indexed for MEDLINE]

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