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J Pediatr. 1987 Dec;111(6 Pt 1):807-12.

Diagnosis of pre-type I diabetes.

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Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262.


Islet cell antibodies were found in 71 of 1169 first-degree relatives (6.1%) from 448 families who had a proband with type I diabetes. Seven children have since become insulin dependent. All had islet cell antibodies and were followed up prospectively with measurement of first-phase insulin production during intravenous glucose tolerance testing. In this group the statistical probability of developing type I diabetes within 12 months with 95% confidence was found to be 59% to 100% when the first-phase insulin secretion was less than 25 microU/mL. The identification of the prediabetes time period should allow an opportunity for intervention in the underlying disease process to determine if the onset of type I diabetes can be altered.

[Indexed for MEDLINE]

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