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Brain Res. 1987 Sep 29;422(1):154-7.

Corticotropin-releasing factor (CRF) produces analgesia in humans and rats.

Author information

1
Clinical Pain Section, National Institute of Dental Research, Bethesda, MD 20892.

Abstract

The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.

PMID:
3315118
DOI:
10.1016/0006-8993(87)90550-6
[Indexed for MEDLINE]

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