Format

Send to

Choose Destination
See comment in PubMed Commons below
Brain Res. 1987 Aug 18;418(1):146-51.

The effects of knife cuts of hippocampal pathways on epileptic activity in the seizure-sensitive gerbil.

Author information

1
Department of Anatomy and Neurobiology, University of California, Irvine 92717.

Abstract

Previous studies have shown morphological differences in the hippocampal formation of seizure-sensitive gerbils as compared to seizure-resistant gerbils. To determine the significance of these differences, lesions were made of hippocampal afferents and efferents. Seizure-sensitive gerbils with bilateral knife cuts of the perforant path, including those with bilateral fornix lesions, showed no seizure activity following surgery. However, bilateral transections of the fimbria of the fornix, unilateral lesions of the perforant path and sham surgeries had no significant effect on seizure activity. The termination of seizure activity with bilateral lesions of the perforant path suggests that this pathway, as opposed to the fornix, is required for motor seizures in this strain of gerbils.

PMID:
3311288
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center