Association of serum fibroblast growth factor 21 and urinary glucose excretion in hospitalized patients with type 2 diabetes

Rui Zhang; Xiaoling Cai; Yongrui Du; Liu Liu; Xueyao Han; Wei Liu; Siqian Gong; Xianghai Zhou; Xiangqing Wang; Xin Wen; Linong Ji

doi:10.1016/j.jdiacomp.2020.107750

Association of serum fibroblast growth factor 21 and urinary glucose excretion in hospitalized patients with type 2 diabetes

J Diabetes Complications. 2021 Jan;35(1):107750. doi: 10.1016/j.jdiacomp.2020.107750. Epub 2020 Oct 7.

Authors

Rui Zhang¹, Xiaoling Cai², Yongrui Du³, Liu Liu⁴, Xueyao Han¹, Wei Liu¹, Siqian Gong¹, Xianghai Zhou¹, Xiangqing Wang¹, Xin Wen¹, Linong Ji⁵

Affiliations

¹ Department of Endocrinology and Metabolism, Peking University People's Hospital, No 11, Xizhimen Nan Da Jie, Xicheng District, Beijing, China.
² Department of Endocrinology and Metabolism, Peking University People's Hospital, No 11, Xizhimen Nan Da Jie, Xicheng District, Beijing, China. Electronic address: dr_junel@sina.com.
³ Department of Endocrinology and Metabolism, Chinese People's Liberation Army 80th Group Military Hospital, 256 Beigong Xi Street, Weifang, Shandong, China.
⁴ Department of Endocrinology and Metabolism, Guiyang Hospital of Guizhou Aviation Industry Group, No 420, Huanghe Street, Guiyang, Guizhou, China.
⁵ Department of Endocrinology and Metabolism, Peking University People's Hospital, No 11, Xizhimen Nan Da Jie, Xicheng District, Beijing, China. Electronic address: jiln@bjmu.edu.cn.

PMID: 33097385
DOI: 10.1016/j.jdiacomp.2020.107750

Abstract

Aim: Urinary glucose excretion (UGE) is mainly regulated by the sodium glucose cotransporter (SGLT)-2 in the proximal tubule of kidney. Lower UGE was associated with higher extent of insulin resistance in patients with type 2 diabetes. Animal studies suggested the relation of Fibroblast growth factor 21 (FGF21) and UGE. However, little was known about the association of FGF21 and UGE in human. We conducted a study to investigate the association of serum FGF21 and low UGE in patients with type 2 diabetes.

Method: A cohort of 2066 hospitalized patients with type 2 diabetes was screened for the fasting urinary glucose concentration and fasting blood glucose in the medical records. 70 patients with high UGE and 61 patients with Low UGE were analyzed. Frozen serum samples were used for the test of FGF21 levels.

Results: The body mass index (BMI) and serum FGF21 levels were higher in low UGE group. Multivariable logistic regression indicated the association of FGF21 and low UGE after adjusting for age, sex, renal function, fasting plasma glucose, the treatment of insulin, and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index.

Conclusion: Higher serum FGF21 levels were independently associated with low UGE in patients with type 2 diabetes.

Keywords: Diabetes; FGF21; Renal glucose threshold; SGLT-2; Urinary glucose excretion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose
Diabetes Mellitus, Type 2* / complications
Fibroblast Growth Factors
Glucose
Humans
Insulin Resistance

Substances

Blood Glucose
FGF21 protein, human
fibroblast growth factor 21
Fibroblast Growth Factors
Glucose