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Nature. 1987 Oct 8-14;329(6139):506-12.

Structure of the human class I histocompatibility antigen, HLA-A2.

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1
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

Abstract

The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices. A large groove between the alpha-helices provides a binding site for processed foreign antigens. An unknown 'antigen' is found in this site in crystals of purified HLA-A2.

PMID:
3309677
DOI:
10.1038/329506a0
[Indexed for MEDLINE]
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