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Clin Chim Acta. 1987 Jun 15;165(2-3):147-54.

Determination of polyamines and metabolites in cerebrospinal fluid by isotope dilution mass fragmentography, and a clinical application.

Author information

1
Central Laboratory for Clinical Chemistry, University Hospital, Groningen, The Netherlands.

Abstract

Capillary gas chromatography and mass fragmentography was used to determine simultaneously 1,3-diaminopropane, putrescine, cadaverine, spermidine, spermine, isoputreanine and putreanine in cerebrospinal fluid. After addition of deuterium labelled analogs and acid hydrolysis, the compounds were isolated by adsorption onto silica and converted into their N-heptafluorobutyryl-methylesters. Quality control data and an application of the method are given. A patient harbouring an astrocytoma was monitored during chemotherapeutic treatment.

PMID:
3308180
DOI:
10.1016/0009-8981(87)90158-6
[Indexed for MEDLINE]

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