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Chest. 1987 Sep;92(3):547-9.

Lung immunogenicity, rejection, and obliterative bronchiolitis.

Abstract

Evidence suggests that obliterative bronchiolitis (OB) following human heart-lung transplantation is a form of allograft rejection related to augmented expression of class II major histocompatibility complex antigens (MHCII) on airway epithelium and mediated by activated T cells. Other forms of OB, including those related to viral infection and autoimmune disease, may reflect a similar mechanism.

PMID:
3304851
DOI:
10.1378/chest.92.3.547
[Indexed for MEDLINE]

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