Insult to Injury-Potential Contribution of Coronavirus Disease-19 to Neuroinflammation and the Development of HIV-Associated Neurocognitive Disorders

AIDS Res Hum Retroviruses. 2021 Aug;37(8):601-609. doi: 10.1089/AID.2020.0136. Epub 2020 Oct 21.

Abstract

Severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 is responsible for a new coronavirus disease known as coronavirus disease-19 (COVID-19). SARS-CoV-2 reports neurotropic properties and may have neurological implications, and this creates another health burden for people living with HIV. As yet, the impact of COVID-19 on (neuro)inflammation and the development of HIV-associated neurocognitive disorders (HAND) is not fully known. Here, we reviewed preliminary evidence that provides clues that COVID-19 may exacerbate inflammatory mechanisms related to the development of HAND.

Keywords: COVID-19; HAND; HIV-associated neurocognitive disorders; SARS-CoV-2; coronaviruses; inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AIDS-Associated Nephropathy / complications*
  • AIDS-Associated Nephropathy / virology
  • COVID-19 / complications*
  • COVID-19 / virology
  • Humans
  • Inflammation / complications*
  • Inflammation / virology
  • Neurocognitive Disorders / complications*
  • Neurocognitive Disorders / virology
  • SARS-CoV-2 / pathogenicity