Abstract
The metolazone-furosemide combination of diuretics was compared with the thiazide-furosemide combination in nephrotic patients with edema. Nine patients underwent a crossover, randomized study receiving furosemide (2 mg/kg per dose) and either metolazone (dose varied according to weight) or chlorothiazide (10 mg/kg per dose). An additive natriuretic and diuretic effect was observed after both metolazone and thiazide were combined with furosemide. The use of both types of diuretic combination was associated with marked kaliuresis. These combinations of diuretics seem equally effective in inducing natriuresis and diuresis in edematous nephrotic patients.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Administration, Oral
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Adolescent
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Benzothiadiazines
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Child
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Child, Preschool
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Clinical Trials as Topic
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Diuretics / administration & dosage*
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Drug Administration Schedule
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Drug Therapy, Combination
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Edema / drug therapy*
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Edema / etiology
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Edema / urine
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Female
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Furosemide / administration & dosage
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Humans
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Male
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Metolazone / administration & dosage
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Natriuresis / drug effects
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Nephrotic Syndrome / complications
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Nephrotic Syndrome / drug therapy*
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Nephrotic Syndrome / urine
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Osmolar Concentration
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Potassium / urine
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Random Allocation
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Sodium Chloride Symporter Inhibitors / administration & dosage
Substances
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Benzothiadiazines
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Diuretics
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Sodium Chloride Symporter Inhibitors
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Furosemide
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Potassium
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Metolazone