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Brain Res. 1988 May 24;449(1-2):332-6.

Dopamine modifies the balance of rod and cone inputs to horizontal cells of the Xenopus retina.

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Department of Ophthalmology, New York University Medical Center, NY 10016.


Dopamine (greater than or equal to 2 microM) increased the cone input and suppressed the rod input to axon-bearing horizontal cells of the Xenopus retina. Dopamine (10 microM) also depolarized the horizontal cell by about 9 mV. The D2-dopamine antagonists spiperone and metoclopramide had the opposite action to dopamine, whereas the D1-dopamine antagonist SCH 23390 was without effect. None of the agents tested modified the light-evoked responses of rods.

[Indexed for MEDLINE]

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