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Nephrologie. 1988;9(1):9-13.

[Sodium transport and renal hemodynamics in arterial hypertension of genetic origin: primary or secondary changes?].

[Article in French]

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Istituto di Scienze Mediche, Scuola di Specializzazione in Nefrologia Medica, Universit√° di Milano.


Essential hypertension develops from the interaction of genetic and environmental factors. In the Milan hypertensive strain (MHS) rat before the development of hypertension, there is a genetically inherited increase of tubular reabsorption which is the cause of the following increase of blood pressure. Also in young normotensive humans, predisposed to develop essential hypertension later in life, there is an abnormal pattern of renal function that may be explained by increase of tubular reabsorption. The studies of the erythrocyte membrane transport support these data and suggest that at least a subset of essential hypertensive humans may develop a form of hypertension that has pathogenetic mechanisms similar to the ones of MHS rats.

[Indexed for MEDLINE]

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