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J Clin Pharmacol. 1988 May;28(5):416-9.

Superactivated charcoal versus cholestyramine for cholesterol lowering: a randomized cross-over trial.

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Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City.


To evaluate the relative abilities of superactivated charcoal (20 g twice daily) and cholestyramine (8 g twice daily) to lower plasma cholesterol concentrations acutely, six hypercholesterolemic patients were studied using a randomized cross-over design. After a 1-week dietary control period, each subject received 3 weeks of each treatment regimen on separate occasions. Superactivated charcoal and cholestyramine reduced total plasma cholesterol by 21.8 +/- 3.8% and 16.2 +/- 2.4%, respectively. Side effects were mild and similar for both treatments. At the dosage regimens studied, superactivated charcoal and cholestyramine have comparable ability to lower plasma cholesterol concentrations.

[Indexed for MEDLINE]

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