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Science. 1988 Jul 1;241(4861):42-52.

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

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Molecular Biology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138.


In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino acid sequences deduced from the nucleotide sequences of molecularly cloned genes or complementary DNAs. Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.

[Indexed for MEDLINE]

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