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Nature. 1988 Jul 7;334(6177):37-42.

Function of a yeast TATA element-binding protein in a mammalian transcription system.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

Saccharomyces cerevisiae contains a protein which is functionally similar to the mammalian TATA element-binding transcription factor, TFIID. The yeast factor substitutes for TFIID in a mammalian RNA polymerase II in vitro transcription system, forms a stable preinitiation complex on the Adenovirus-2 major late promoter, and binds specifically to the TATA boxes of the viral promoter and the yeast CYC1 promoter. Interestingly, the yeast factor promotes initiation at a distance from the TATA element typical of a mammalian system.

PMID:
3290687
DOI:
10.1038/334037a0
[Indexed for MEDLINE]

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