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Proc Natl Acad Sci U S A. 1988 Jun;85(12):4491-5.

Immunological identification of a high molecular weight protein as a candidate for the product of the Duchenne muscular dystrophy gene.

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Department of Biochemistry and Molecular Biology, University of Cincinnati College of Medicine, OH 45267-0522.


An oligopeptide was synthesized based on translation of the nucleotide sequence of the putative exon region of clone pERT87-25 from the gene for Duchenne muscular dystrophy. Immunization of rabbits with this oligopeptide induced the formation of antibodies directed against a protein present in human, rat, and rabbit skeletal muscle. This protein, which is missing in the skeletal muscle of two patients with Duchenne muscular dystrophy, has a molecular mass of approximately equal to 320-420 kDa and is clearly different from the putative Duchenne muscular dystrophy-related protein nebulin. The data suggest that this 320- to 420-kDa protein is produced by the Duchenne muscular dystrophy gene.

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