Finding the optimal signal timing strategy is a difficult task for the problem of large-scale traffic signal control (TSC). Multiagent reinforcement learning (MARL) is a promising method to solve this problem. However, there is still room for improvement in extending to large-scale problems and modeling the behaviors of other agents for each individual agent. In this article, a new MARL, called cooperative double Q -learning (Co-DQL), is proposed, which has several prominent features. It uses a highly scalable independent double Q -learning method based on double estimators and the upper confidence bound (UCB) policy, which can eliminate the over-estimation problem existing in traditional independent Q -learning while ensuring exploration. It uses mean-field approximation to model the interaction among agents, thereby making agents learn a better cooperative strategy. In order to improve the stability and robustness of the learning process, we introduce a new reward allocation mechanism and a local state sharing method. In addition, we analyze the convergence properties of the proposed algorithm. Co-DQL is applied to TSC and tested on various traffic flow scenarios of TSC simulators. The results show that Co-DQL outperforms the state-of-the-art decentralized MARL algorithms in terms of multiple traffic metrics.