Posterior reversible encephalopathy syndrome case report in an untreated, normotensive, ovarian cancer patient in the presence of paraneoplastic antibodies

BMC Neurol. 2020 Sep 2;20(1):330. doi: 10.1186/s12883-020-01913-y.

Abstract

Background: Posterior reversible encephalopathy syndrome (PRES) is a rare neurological condition with many associated risk factors. The presentation varies and consists of seizures, impaired visual acuity or visual field deficits, disorders of consciousness, headaches, confusion and focal neurological deficits. The diagnosis relies on clinical presentation and MRI findings. Treatment and prognosis are related to the underlying etiology.

Case presentation: We present a 58-year-old woman with ovarian cancer who developed symptoms and radiologic signs of PRES with no apparent trigger other than a sudden increase in blood pressure for the first time in her life and before any treatment has begun. Antibodies to collapsin response-mediator protein-5 (CRMP-5), a malignancy related paraneoplastic protein, were identified in her CSF.

Conclusions: We present a novel and intriguing association between PRES and antibodies against CRMP-5 which may highlight a new etiology for this condition.

Keywords: CRMP5; Ovarian cancer; PRES; Paraneoplastic antibodies; Posterior reversible encephalopathy syndrome.

Publication types

  • Case Reports

MeSH terms

  • Blood Pressure
  • Confusion / etiology
  • Female
  • Headache / etiology
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Ovarian Neoplasms / pathology*
  • Posterior Leukoencephalopathy Syndrome / etiology*
  • Risk Factors
  • Seizures / etiology